Diederik Hentenaar

40 Chapter 2 Table 3b. Median (IQR) biomarker levels in the peri-implantitis group at baseline (PI T0) and 3 months after treatment (PI T3) Biomaker (median; [IQR]) Implant status Lum-30sec (pg/ml) PI T0 vs PI T3 Lum-30sec (pg) PI T0 vs PI T3 modConc [pg/μl] PI T0 vs PI T3 Luminex-30sec (pg/ml) p value Luminex-30sec (pg) p value modConc [pg/μl] p value IL-1β PI T0 783.5 [414.0;2607.3] 0.156 58.8 [31.1;195.5] 0.156 57.9 [38.0;158.9] 0.145 PI T3 738.5 [358.3;1516.8] 55.4[26.9;113.8] 47.1 [21.5;123.4] IL-6 PI T0 30.6 [10.6;67.4] 0.247 2.3 [0.8;5.1] 0.227 1.7 [0.8;1.3] 0.003 PI T3 38.5 [11.3;76.4] 2.9 [0.9;5.7] 2.1 [1.1;6.2] TNF-α PI T0 13.0 [10.5;20.4] 0.247 1.0 [0.8;1.5] 0.219 1.1 [0.8;1.3] 1.000 PI T3 11.5 [9.0;16.8] 0.9 [0.7;1.3] 0.9 [0.7;1.4] MCP-1 PI T0 58.2 [40.3;92.8] 0.526 4.4 [3.0;7.0] 0.514 5.2 [2.8;6.6] 0.709 PI T3 57.6 [40.0;120.3] 4.31[3.2;9.0] 4.1 [2.4;6.6] MIP-1α PI T0 10.8 [7.2;17.9] 0.001 0.8 [0.5;1.4] 0.001 0.8 [0.5;1.5] 0.012 PI T3 14.9 [9.4;30.0] 1.13[0.7;2.2] 0.9 [0.8;2.7] MMP-8 PI T0 34829.5 [24145.0;41791.5] 0.167 2612.2 [1810.8;3134.4] 0.167 1974.7 [1292.1;3895.6] 0.028 PI T3 36775.0 [23351.5;65973.3] 2758.1[1751.4;4947.9] 3288.0 [1582.9;5359.8] OPG PI T0 33.9 [20.3;66.2] 0.526 2.5 [1.6;5.0] 0.588 2.2[1.3;4.1] 0.411 PI T3 32.4 [25.0;59.0] 2.4 [1.9;4.4] 2.89 [1.6;4.2] G-CSF PI T0 0.0 [0.0;24.0] < .001 0.0 [0.0;1.8] < .001 0.0 [0.0;1.3] < .001 PI T3 32.3 [26.8;41.6] 2.4 [2.0;3.1] 2.39[1.8;3.6] Note: Outcomes presented in Luminex™ concentration per 30-seconds in pg/mL, Luminex™ concentration in pg per 30-seconds (corrected for 75μl elution) and as modified concentration [in pg/μL]; corrected for 75μl elution and PICF volume. Wilcoxon signed-rank test significant outcome p < 0.05. Abbreviation: IQR, interquartile range.