Diederik Hentenaar

89 Erythritol air-polishing in surgical peri-implantitis treatment 4 Chapter 4 Figure 1. Flow diagram Analysis of primary and secondary outcomes, inten � on to treat analysis (n = 27 pa � ents, 54 implants) Analysis for primary and secondary outcomes, inten � on to treat analysis (n = 31 pa � ents, 40 implants) Lost to follow-up (n= 0) Discon � nued the study (n= 4 pa � ents, 6 implants) Discon � nued the study between surgery and T3 (n = 1) 1 pa � ent/1 implant; 1 out of 1 implant removed due to implant failure (mobility). Discon � nued the study a � er T3 (n = 1) 1 pa � ent/2 implants; 2 out of 2 implants removed a� er T3 due to persis � ng peri- implan �� s Discon � nued the study a � er T6 (n = 1) 1 pa � ent/1 implant; 1 out of 1 implants removed a�e r T6 due to persis � ng peri-implan �� s Discon � nued the study a � er T9 (n = 1) 1 pa � ent/2 implants; 2 out of 2 implants removed due to persis � ng peri-implan �� s Lost to follow-up (n= 0) Discon � nued the study (n= 8 pa � ents, 10 implants) Discon � nued the study a � er T3 (n = 1) 1 pa � ent/1 implant; 1 out of 1 implants removed a� er T3 Discon � nued the study a � er T6 (n = 4) 4 pa � ents/ all 1 implant; 1 out of 1 implants removed a� er T3 due to persis � ng peri- implan �� s 1 pa � ent/2 implants; 2 out of 2 implants removed due to persis � ng peri-implan �� s Discon � nued the study a � er T9 (n = 2) 1 pa � ent/2 implants; 2 out of 2 implants removed due to persis � ng peri-implan �� s 1 pa � ent/1 implant 1; 1 out of 1 implants removed due to persis � ng peri-implan �� s Follow-Up Allocated to test group (n = 27) Received allocated interven � on (n = 26) Did not receive allocated interven � on (n = 1) - Implant removed during surgery due to implant failure (mobility) Allocated to control group (n = 31) Received allocated interven � on (n = 31) Did not receive allocated interven � on (n = 0) Alloca � on Enrollment Excluded (n = 4) Declined to par � cipate (n = 4) Assessed for eligibility (n = 62) Analysis Randomized (n = 58) Figure 1. Flow diagram 4

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