Geert Kleinnibbelink

Chapter 4 112 was determined, after which Uncoupling ED was calculated as the sum of the differences at the lowest two-thirds of increments of EDA in the working range of the heart, and Uncoupling LD was calculated as the sum of the differences at the highest one-third of increments of EDA in the working range of the heart. RV area (cm 2 ) RV longitudinal strain (%) ESA EDA a. EarlySslope b. Sslope c. Peak strain d. Uncoupling EarlyD e. Uncoupling LateD f. Uncoupling g. EarlyDslope h. LateDslope 0 0 -21 a b c e d 100% of EDA 40% of EDA 25 f g h Figure 1 . Strain-area loop. The linear strain-area slope (b. Sslope) and early strain-area slope during first 5% of volume ejection in systole (a. ESslope); (II) end-systolic peak longitudinal strain (c. peak strain); (III) the early linear strain-area slope during first 5% (g. EDslope) and late linear strain-area slope (h. LDslope) during last 5% of volume increase in diastole; and (IV) diastolic uncoupling (f.) (i.e. difference in strain between systole and diastole at any given area), divided into uncoupling during early (d. Uncoupling ED) and late diastole (e. Uncoupling LD).