Geert Kleinnibbelink

Chapter 5 122 was conducted to compare 1) pre- and post-exercise training data and 2) conditions. A Greenhouse-Geisser correction was used for estimating P-values if the sphericity assumption was violated (P > 0.05, tested with Mauchly’s test). A Sidak post-hoc correction was used to account for multiple testing. Associations between acute PEH and chronic BP lowering effects were analysed by Pearson’s correlation coefficient and compared using Fisher Z-transform, in which acute is defined as the BP response to a single bout of high intensity hypoxic exercise and chronic as the change in post-acclimated resting BP following a 12-week training program. An alpha level of p ≤ 0.05 was accepted a priori for significance. RESULTS Participants were aged 22.2±3.0 years, had a body mass of 69.5±10.7 kg, a VO 2 max/kg of 52.4±8.1 mL/min/kg and were all normotensive ( < 140/90mmHg). All participants were non-smokers. Baseline characteristics are shown in Table 1 . Fifteen of the 21 included participants completed the chronic part of the study ( Table 2 ). Table 1. Subject characteristics: baseline Sex (m/f ) 14/7 Age (yr) 22.2±3.0 Height (cm) 170.3±10.4 Body Mass (kg) 69.5±10.7 BMI (kg/m2) 24.0±2.7 BSA (kg) 1.81±0.18 Resting HR (bpm) 65±8 Resting SBP (mmHg) 119±5 Resting DBP (mmHg) 69±8 Resting MAP (mmHg) 85±6 SpO2 (%) 98.4±1.2 VO 2 max (L/min) 3.6±0.7 VO2max/kg (mL/min/kg) 52.4±8.1 VE (L/min) 138±28 Hrmax (bpm) 199±8 Data are expressed as means±SD. m, male. f, female. BMI, body mass index. BSA, body surface area. HR, heart rate. SBP, systolic blood pressure. DBP, diastolic blood pressure. MAP, mean arterial pressure. SpO2, oxygen saturation. VO 2 max, maximal oxygen uptake. VE, ventilation.