Geert Kleinnibbelink

Chapter 6 146 Table 2. Values of right ventricular longitudinal strain and hazard ratios extracted from the included studies First author Absolute values of RVLS (mean±SD) Cut-off Relative reduction of RVLS (%) HR ratio [95% CI] Log (HR) SE Healthy controls PH-patients PH-patients above cut-off value PH-patients below cut-off value Dichotomous Continuous Combined endpoint da Costa et al. 7 -27.5±2.4% -16.1±6.8% < -14% 13% 4.66 (1.25-7.37) 1.53902 0.67132 Fine et al. 8 -25.0±5.2% -19.6±6.6% -6.7% 26% 1.27 (1.04-1.56) 0.23902 0.10343 Giusca et al. 11 -17.3±7.2% -1% 6% 1.22 (0.92-1.62) 0.19885 0.14434 Moceri et al. 29 † -14.1±3.6 -8.4±3.6% -1% 12% 1.15 (0.95-1.40) 0.13976 0.09892 Murata et al. 21 -19.9±6.4% -1% 5% 1.05 (0.97-1.15) 0.04879 0.04342 Park et al. 10 -16.1±5.0% -5% 31% 2.09 (1.05-4.15) 0.75142 0.26639 Unlu et al. 26* -16.6% # -1% 5% 1.23 (1.04-1.45) 0.20701 0.08515 All-cause mortality Haeck et al. 15 -23.5±3.7% -14.0±3.5 < -19% 19% 3.40 (1.19-9.72) 1.22378 0.53577 van Kessel et al. 9 -24.8±4.0% -15.9±2.9 < -20% 19% 4.30 (1.11-16.61) 1.45861 0.69022 Park et al. 10 -16.1±5.0% -5% 31% 2.08 (1.13-3.80) 0.73716 0.35059 Sachdev et al. 23 -15±5.0% -5% 33% 2.00 (1.11-3.96) 0.69315 0.32446 Vitarelli et al. 28 † -23.8±5.8 -18.8% # < -17% 10% 4.60 (2.79-8.38) 1.52606 0.28056 Symbols denote *=Inverse HR with respect to original article, † =3D strain analysis and # =mean value calculated frommultiple groups. (RVLS=Right Ventricular Longitudinal Strain; HR=Hazard Ratio; SE=Standard Error)