Geert Kleinnibbelink

RV Strain-Area Loop following Selexipag 8 177 A) All (n=8) B) Responders (n=3) C) Non-Responders (n=5) Pre Post p-value Pre Post p-value Pre Post p-value Functional and Doppler measure- ments RV global longitudinal strain (%) -16.2±4.2 -16.3±3.9 0.92 -14.5±3.8 -16.7±3.6 0.01 -17.2±4 -16.0±4.5 0.04 RV fractional area change (%) 39±11 39±5 0.98 35±5 39±3 0.14 41±13 38±6 0.53 TAPSE (cm) 2.2±0.6 2.4±0.5 0.46 2.2±0.7 2.5±0.2 0.37 2.2±0.6 2.3±0.7 0.88 TDI s’ (cm/s) 11±3 12±4 0.79 12±1 14±1 0.20 12±4 11±4 0.11 TDI e’ (cm/s) 11±4 11±2 0.60 14±1 11±1 0.20 11±5 11±3 0.76 TDI a’ (cm/s) 15±4 17±6 0.55 13±4 19±5 0.13 16±4 15±6 0.21 PAT (ms) 97±23 94±22 0.76 93±6 93±19 0.93 98±27 94±25 0.62 TR Vmax (m/s) 4.3±0.6 4.0±0.8 0.27 4.5±0.3 3.8±0.6 0.33 4.2±0.7 4.1±1.0 0.74 TR maxPG (m/s) 75±20 66±26 0.31 81±10 59±19 0.30 72±24 71±33 0.86 Data are expressed as means±SD. 6MWT, 6-minute walking distance. ED, Early diastole. ES, Early systole. GFR, glomerular filtration rate. LD, Late Diastole. PAT, pulmonary acceleration time. PG, pressure gradient. PLAX, Parasternal long axis. PSAX, parasternal short axis. RA, Right atrium. RV, Right ventricle. RVFAC, RV fractional area change. RVEDA, Right ventricular end-diastolic area. RVESA, Right ventricular end-systolic area. RVOT, Right ventricular outflow tract. TAPSE, Tricuspid annular plane systolic excursion. TDI, Tissue Doppler imaging. TR, Tricuspid. V, velocity. Table 1 . (Continued)