Geert Kleinnibbelink

Cardiac Rehabilitation in Pulmonary Hypertension 9 189 with mortality of 13.9% (n=87 of 628 patients) in the CR and exercise cohort compared to 21.0% (n=133 of 632 patients) in the controls (OR 0.60,.95% CI 0.45-0.81). There was no significant effect on re-hospitalisation (OR 0.93, 95% CI 0.75-1.16), with re-hospitalisations rates of 55.4% (n=350 out of 632 patients) in the CR and exercise cohort, compared to 57.1% (n=361 out of 632 patients) in the controls. Table 1. Baseline characteristics % (n)* of the primary PH populations with and without CR before and after propensity score matching. Initial populations Propensity score matched populations Primary PH without CR (n=70,875) Primary PH with CR (n=637) P-value Primary PH without CR (n=632) Primary PH with CR (n=632) P-value Age (years), mean (SD) 62.0 (14.5) 60.0 (20.7) 0.01 62.7 (14.5) 62.2 (14.3) 0.51 Female 62.8 (43,467) 43.9 (279) <0.0001 43.5 (275) 44.1 (279) 0.82 Race a White 63.6 (43,997) 71.2 (452) <0.0001 73.3 (463) 71.4 (451) 0.45 Black or African American 21.6 (14,961) 19.7 (125) 0.24 20.3 (128) 19.8 (125) 0.83 Asian 1.8 (1,214) 1.7 (11) 0.97 1.6 (10) 1.7 (11) 0.83 Unknown 12.7 (8,769) 5.8 (37) <0.0001 4.6 (29) 5.8 (37) 0.31 Diseases of the circulatory system 71.2 (49,286) 99.7 (633) <0.0001 99.2 (627) 99.7 (630) 0.26 Diseases of the respiratory system 46.3 (32,021) 85.0 (540) <0.0001 86.6 (547) 85.0 (537) 0.42 Hypertensive Diseases 43.2 (31,959) 83.9 (533) <0.0001 86.2 (545) 83.9 (530) 0.24 Heart Failure 27.6 (19,076) 80.0 (508) <0.0001 78.6 (497) 79.9 (505) 0.58 Diabetes Mellitus 21.5 (14,878) 47.7 (303) <0.0001 48.9 (309) 47.6 (301) 0.65 Chronic Kidney Disease 14.9 (10,318) 42.4 (269) <0.0001 44.8 (283) 42.6 (269) 0.43 Cerebrovascular Diseases 9.1 (6,291) 27.7 (176) <0.0001 27.8 (176) 27.5 (174) 0.90 Cardiovascular Procedures b 47.1 (32,568) 97.3 (617) <0.0001 97.6 (617) 97.3 (615) 0.72 Cardiovascular Medications c 56.3 (38,974) 95.1 (604) <0.0001 94.5 (597) 95.1 (601) 0.61 *Values are % (n) unless otherwise stated. Baseline characteristics were compared using a chi- squared test for categorical variables and an independent-sample t-test for continuous variables. a Data are taken from structured fields in the electronic medical record systems of the participating healthcare organizations, therefore, there may be regional or country-specific differences in how race categories are defined. b Cardiovascular procedures include cardiography, echocardiography, catheterization, cardiac devices, electrophysiological procedures. c Cardiovascular medications include beta-blockers, antiarrhythmics, diuretics, antilipemic agents, antianginals, calcium channel blockers, ACE inhibitors. CR; cardiac rehabilitation and exercise programmes, SD; standard deviation.