Geert Kleinnibbelink

General Discussion 10 199 Acute responses to exercise Chronic responses to exercise Physiologic remodelling Maladaptation? A B C Exercise-induced increase in cardiac function Exercise-induced cardiac fatigue Post-exercise hypotension Associated with chronic blood pressure reduction Figure 1. The relation between acute cardiac responses and chronic cardiac responses to exercise. Acute exercise leads to (A) an increase in cardiac function, (B) exercise-induced cardiac fatigue or (C) post-exercise hypotension. In this thesis, we investigated the acute and chronic effects of exercise on the cardiovascular system. Specifically, we investigated (A) the associations between exercise- induced increase in cardiac function and cardiac remodelling to exercise training (Chapter 3, discussion paragraph 10.2), (B) the effect of hypoxic exercise on and value of stress echocardiography in the assessment of exercise-induced cardiac fatigue (Chapter 2, discussion paragraph 10.1.1) and speculated on its potential meaning (discussion paragraph 10.1.1) and (C) the associations between post-exercise hypotension and chronic blood pressure reduction to exercise training (Chapter 5, discussion paragraph 10.1.2).