Geert Kleinnibbelink

Chapter 10 206 Table 1. RV and LV strain prior to and post 12-week hypoxic training program Pre-training Post-training Rest echocardiogram Stress echocardiogram Rest echocardiogram Stress echocardiogram P-Value Pre Post Pre Post Pre Post Pre Post E T S E*T E*S E*T*S RV FreeWall strain (%) -28.3±0.6 -27.8±0.6 -32.4±0.9 -29.4±0.7 -27.7±0.6 -26.4±0.8 -33.8±0.7 -30.3±0.8 <0.001 0.88 <0.001 0.36 0.06 0.89 LV Global longitudi- nal strain (%) -20.8±0.3 -19.7±0.3 -22.9±0.4 -21.7±0.4 -20.3±0.2 -19.0±0.3 -22.7±0.4 -20.7±0.4 <0.001 0.04 <0.001 0.25 0.26 0.28 Data are expressed as means±SEM. RV, Right ventricle. LV, Left ventricle. Linear mixed models factors: E, Exercise: Comparison between all echocardiographic measurements performed pre vs. post 45-minutes high intensity exercise. T, Training: Comparison between all echocardiographic measurements performed pre vs. post 12-week training programme. S, Stress: Comparison between all echocardiographic measurements performed under rest vs. during stress. E*T, Exercise*Training: Comparison whether the change pre- vs. post-exercise (i.e. EICF) is different pre vs. post 12-week training programme. E*S, Exercise*Stress: Comparison whether the change pre- vs. post-exercise (i.e. EICF) is different measured during rest vs. stress echocardiography. E*T*S, Exercise*Training*Stress: Comparison whether the change pre- vs. post-exercise (i.e. EICF) is different pre vs. post 12-week training programme when observed using rest vs. stress echocardiography.