Geert Kleinnibbelink

General Discussion 10 215 valuable tool to follow-up patients with PAH. Future studies should explore further its clinical utility in this and other patient groups. Development of a semi-automatedmethod is key for an eventual integration into daily clinical practice. Lastly, we showed that exercise training causes rapid right-sided cardiac adaptation (in healthy individuals), but also that exercise-based CR reduces all-cause mortality in patients with primary PH. Moreover, we described that exercise training in coronary heart disease has strong inter-individual effects. Whilst our work highlights the role and clinical benefits of exercise, further improving these benefits would require insight into patient and exercise characteristics. Ultimately, this will enhance the benefits of CR and will contribute to exercise as personalised medicine in cardiovascular disease.