Geert Kleinnibbelink

Exercise-Induced Cardiac Function under Hypoxia 2 39 Table 1. Subject characteristics Sex (m/f ) 14/7 Age (yr) 22.2±0.6 Height (cm) 170±2 Body Mass (kg) 70±2 BMI (kg/m2) 24.0±0.6 BSA (m2) 1.8±0.04 Resting HR (bpm) 65±2 Resting SBP (mmHg) 119±1 Resting DBP (mmHg) 69±2 Resting MAP (mmHg) 85±1 resting SpO2 (%) 98.4±0.3 VO 2 max (L/min) 3.6±0.1 VO 2 max/kg (mL/min/kg) 52±2 VE (L/min) 138±6 HRmax (bpm) 199±2 Data are expressed as means±SEM. m, male. f, female. BMI, body mass index. BSA, body surface area. HR, heart rate. SBP, systolic blood pressure. DBP, diastolic blood pressure. MAP, mean arterial pressure. SpO2, oxygen saturation. VO 2 max, maximal oxygen uptake. VE, ventilation. Study design In this randomized crossover trial, participants attended the laboratory on three separate occasions ( Figure 1 ). During the first visit, a medical screening was performed to determine eligibility of the potential participants. After signing informed consent, baseline measurements were performed. Visits two and three included performance of a bout of 45-minute high-intensity running exercise under normobaric hypoxia or normoxia, which were performed in a randomized order. Participants were blinded for the order of test days and abstained from exercise for a minimum of 48 hours, and from alcohol and caffeine consumption 24 hours before the test days.