Geert Kleinnibbelink

Chapter 2 46 exercise there was a reduction in RV longitudinal strain, uncoupling and uncoupling LD (Exercise: p < 0.05) without a rightward shift (RVEDA Exercise: p > 0.05) ( Table 2 Figure 4A,B ). Figure 3 . Right ventricular longitudinal strain (A) and left ventricular longitudinal strain (B) prior to and post 45-minutes high intensity running exercise. Error bars reflect the standard error of the mean. Linear mixedmodels factors: E, Exercise: Comparison between all echocardiographic measurements performed pre vs. post 45-minutes high intensity exercise. H, Hypoxia: Comparison between all echocardiographic measurements performed under hypoxic vs. normoxic conditions. S, Stress: Comparison between all echocardiographic measurements performed during rest vs. during stress. H*E, Hypoxia*Exercise: Comparison whether the change pre- vs. post-exercise (EICF) is different during hypoxic vs. normoxic conditions. E*S, Exercise*Stress: Comparison whether the change pre- vs. post-exercise is different measured during rest vs. stress echocardiography. E*H*S, Exercise*Hypoxia*Stress: comparison whether the change pre- vs. post-exercise under hypoxic vs. normoxic conditions was different when observed using rest vs. stress echocardiography. Exercise under hypoxia. Under hypoxia, PAT was significantly shorter, RA size significantly larger, late diastolic uncoupling (Uncoupling LD) significantly lower, and a trendwas found for a lower systolic slope (Sslope) compared to normoxic conditions (Hypoxia: p=0.04, p=0.04, p < 0.001, p=0.07, respectively, Table 2, Figure 4A,B ). Importantly, hypoxia did not alter the impact of exercise and/or stress on indices of RV function (Hypoxia*Exercise and Exercise*Hypoxia*Stress: all p > 0.05, Table 2 ).