Geert Kleinnibbelink

Exercise-Induced Cardiac Function under Hypoxia 2 47 RV area (cm 2 ) RV area (cm 2 ) 9 0 23 21 19 17 15 13 11 -5 -10 -15 -20 -25 -30 9 0 23 21 19 17 15 13 11 -5 -10 -15 -20 -25 -30 RV longitudinal strain (%) RV longitudinal strain (%) A) B) Pre stress normoxia Pre stress hypoxia Post stress normoxia Post stress hypoxia Pre stress normoxia Pre stress hypoxia Post stress normoxia Post stress hypoxia Figure 4. Right ventricular strain-area loops prior to and post 45-minute high intensity running exercise during rest (A) and stress (B). Red and blue lines indicating normoxic and hypoxic exercise, respectively. Solid and dotted lines reflecting pre- and post-exercise, respectively. Intra-observer variability . ICC and LOA for RV strain-area loop characteristicswere as follows: RV free wall strain ICC 0.95 (0.89-0.98), LOA 0.33 (-1.55, 2.21); Sslope ICC 0.91 (0.80-0.97), LOA -0.05 (-0.30, 0.20); ESslope ICC 0.60 (0.23-0.82), LOA 0.60 -0.17 (-1.20, 0.86); EDslope ICC 0.93 (0.84-0.97), LOA 0.19 (-0.37, 0.75); LDslope ICC 0.95 (0.87-0.98), LOA -0.30 (-0.93, 0.32); Uncoupling ICC 0.88 (0.73-0.95), LOA -0.27 (-2.36, 1.81); Uncoupling_ED ICC 0.86 (0.68-0.94), LOA -0.31 (-2.63, 2.01); Uncoupling_LD ICC 0.88 (0.72-0.95), LOA -0.20 (-2.25, 1.86).