Geert Kleinnibbelink

Chapter 3 78 Table 3. Right ventricular acute functional responses to exercise pre-training program Rest Stress delta p-value HR (bpm) 75±9 113±5 38±9 <0.001 Function RVFAC (%) 46.9±2.3 52.0±4.9 5.1±4.7 0.002 TAPSE (mm) 27.3±2.6 30.7±3.4 3.4±3.4 0.002 TDI s’ (cm/s) 15.8±2.2 20.1±2.6 4.3±2.9 <0.001 RV free wall strain (%) -27.5±2.5 -32.0±3.1 -4.5±3.8 0.001 Uncoupling (%) 1.5±1.2 0.8±1.8 -0.7±2.1 0.25 Strain-area loop Uncoupling ED (%) 1.6±1.3 0.7±2.0 -0.8±2.4 0.25 Uncoupling LD (%) 1.4±0.9 0.9±1.6 -0.5±1.8 0.30 Sslope (%/cm2) 2.4±0.4 2.5±0.4 0.1±0.4 0.20 ESslope (%/cm2) 2.4±0.6 3.0±0.7 0.6±1.1 0.07 EDslope (%/cm2) 1.6±0.5 1.5±0.5 -0.1±0.5 0.38 LDslope (%/cm2) 3.1±0.8 3.4±1.1 0.4±0.7 0.11 Data are expressed as means±SD. HR, Heart rate. RVFAC, RV fractional area change. TAPSE, tricuspid annular plane systolic excursion. TDI, tissue doppler imaging. Uncoupling ED, Uncoupling early diastole. Uncoupling LD, Uncoupling late diastole. Figure 4. Correlation between acute increase in RV fractional area change during first exercise session under hypoxia (visit 2) and increase in resting RV basal diameter at completion of the training protocol