Marga Hoogendoorn

162 Appendix 6. Baseline characteristics all other hospitals in the NICE database Patient factors: Patient type COVID-19 vs pneumonia patients Non-COVID vs non-pneumonia patients COVID-19 patients Pneumonia- patients p-value Non-COVID patients Non-pneumonia patients p-value Number of patients – N (%) 2,514 (13.1 %) 1,837 (8.0%) 16,673 (86.9 %) 2262 (92.0%) ICU admission type: Medical patients – N (%) Elective surgical patients – N (%) Urgent surgery patients – N (%) 2,480 (98.6) 10 (0.4) 20 (0.8) 1,834 (99.8) 0 (0) 1 (0.1) <0.001 0.007 0.001 8,634 (51,8) 5,843 (35.0) 2,095 (12.6) 10,667 (50.7) 7,740 (36.8) 2,591 (12.3) 0.040 0.001 0.440 Comorbidities: Diabetes Mellitus – N (%) Renal insufficiency – N (%) Cardiovascular insufficiency – N (%) Respiratory insufficiency – N (%) 472 (18.8) 68 (2.7) 29 (1.2) 283 (11.3) 368 (20.0) 177 (9.6) 84 (4.6) 738 (40.2) 0.287 <0.001 <0.001 <0.001 2,720 (16.3) 914 (5.5) 797 (4.8) 2,185 (13.1) 34,41 (16.3) 1,355 (6.4) 994 (4.7) 3,195 (15.2) 0.955 <0.001 0.809 <0.001 Apache-APS score – Median (IQR) 45 (36-56) 53 (41 – 69) <0.001 39 (27 – 58) 37 (26 – 55) <0.001 Age – Median (IQR) 65 (56 – 72) 69 (59 – 77) <0.001 65 (54 – 73) 66 (54 – 74) <0.001 BMI – Median (IQR) 27.8 (25.3-31.2) 25.5 (22.5 – 29.2) <0.001 26.1 (23.4 – 29.4) 26.1 (23.4 – 29.6) 0.675 Mechanical ventilation in first 24 hours-N (%) 1,959 (77.9) 1,038 (56.5) <0.001 8,060 (48,3) 9,568 (45.4) <0.001 Mortality ICU-mortality - N (% In hospital mortality – N (%) 462 (18.4) 715 (28.4) 339 (18.5) 475 (25.9) 0.959 0.064 1,529 (9.2) 2,141 (12.8) 1,771 (8.4) 2,482 (11.8) 0.014 0.003 Length of ICU stay in days – Median (IQR) 16 (8 – 28) 3.1 (1.4 – 7.4) <0.001 1 (0.8 – 2.5) 1 (0.8 – 2.7) 0.021