Marga Hoogendoorn

COLOPHON Cover design: James Jardine | www.jamesjardine.nl Layout: James Jardine | www.jamesjardine.nl Print: Ridderprint | www.ridderprint.nl ISBN: 978-94-6416-953-9 Sponsored by: Wetenschapsfonds Medisch Specialisten Isala, Stichting NICE, Itémedical B.V. and Klinische Informatiekunde Amsterdam UMC. Copyright © 2021 by Marga E. Hoogendoorn. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.