Iris de Nie

17 GENERAL INTRODUCTION AND THESIS OUTLINE 1 Subsequently, in chapter 6 we will assess if trans women can cryopreserve germ cells, obtained from their orchiectomy specimen at time of GAS, for fertility preservation, after having used puberty suppression and/or hormonal treatment. We will compare outcome between different Tanner stages at time of the start of medical treatment and hereby specifically evaluate options for those who start their medical transition in early puberty. In the second part of this thesis, we focus on testicular cancer risk ( chapter 7 ) and prostate cancer risk ( chapter 8 ) in trans women using GAHT, by comparing the incidence of both cancers in our cohort with the incidence in the general population. Hereby, we will assess the influence of sex steroids on the development of cancer in the male genital tract and explore the need for regular screening. Lastly, chapter 9 of this thesis provides a summary of the main findings, a general discussion and an elaboration on perspectives for (new) life after transition.