Iris de Nie

37 IMPAIRED SEMEN QUALITY IN TRANS WOMEN 3 range 0.1-3.1) and in only 26.4% of thawed semen samples was the quality adequate for a minimally invasive IUI. Limitations, reasons for caution: Limitations include the retrospective design and insufficient data on transgender specific factors, such as bringing the testes into the inguinal position (tucking), wearing tight underwear and low masturbation frequency. Wider implications of the findings: Semen quality in trans women was decreased compared to the general population, which could not be explained by known risk factors, such as BMI, alcohol consumption, cannabis use, gender-affirming hormone use or abnormal endocrine laboratory results. Although a negative impact of smoking was observed, it was insufficient to explain the overall decreased semen quality in this cohort. Since low pre-freeze semen quality results in an even lower post-thaw semen quality, the majority of trans women and their female partner or surrogate may need an invasive and burdensome treatment to establish a pregnancy.