Iris de Nie

56 C H A P T E R 4 RESULTS Description of the study cohort In total, 113 transgender women were included. Baseline characteristics are shown in Table 1. Serum testosterone and FSH concentrations were in the normal range, and alcohol consumption, smoking status, cannabis use and BMI were comparable with the general Dutch population of similar age. 74 Six transgender women reported to have used self- obtained gender-affirming hormones but discontinued this treatment a median 3.8 months (IQR 2.5-6.0) prior to semen cryopreservation. In our cohort 40 transgender women (35.4%) suffered from anxiety or depression and 24 (21.2%) reported previous urological problems, among which orchiopexy (n=5), testicular torsion (n=1) or epididymo-orchitis (n=1). In total, 46 transgender women (40.7%) reported to be solely attracted to women, 25 (22.2%) were solely attracted to men, and 40 (35.3%) were attracted to both women and men. Table 1. Characteristics of study cohort (n=113) Percentage (n) Mean (SD) or Median (IQR) Dutch reference values` Age at time of fertility counseling (years) 24.1 (SD 5.8) FSH (U/L)^ 3.5 (SD 3.3) 1.0-10.5 Testosterone (nmol/L)~ 17.2 (SD 6.6) 9.0-30.0 BMI (kg/m 2 ) Underweight: < 18.5 Normal weight: 18.5-25.0 Overweight: > 25.0 15.9% (18) 56.6% (64) 27.4% (31) 23.3 (SD 5.4) 4.5% 63.8% 31.7% Alcohol Non drinker Current drinker Units/week 48.7% (55) 51.3% (58) 1.0 (IQR 1.0-4.0) 14.3% 85.7% 9.8 Smoking Never Previous smoker Current smoker Cig/day 66.4% (75) 15.0% (17) 18.6% (21) 5.5 (3.0-10.0) 54.9% 14.5% 30.6% Cannabis use Never Sporadically Weekly 81.4% (92) 6.2% (7) 12.4% (14) 18.8% 12.5% Previous hormone use Yes No 5.3% (6) 94.7% (107) History of urological problems* Yes No 21.2% (24) 78.8% (89) History of anxiety or depression Yes No 35.4% (40) 64.6% (73) Sexual dysfunction Yes No 4.4% (5) 95.6% (108) Data available for ^107 for ~109 transgender women *Urological problems include genital/inguinal surgery (e.g. orchiopexy, inguinal hernia repair, varicocele repair), scrotal infection (e.g. epididymitis, orchitis) and testicular torsion. `Data on BMI, alcohol consumption, smoking and cannabis use are obtained from the online database of Statistics Netherlands. 74 SD: standard deviation, IQR: interquartile range.