Iris de Nie

74 C H A P T E R 5 Patient 1 Patient 2 Patient 3 Patient 4 Cessation of anti-androgens/ oestrogen Rationale wants to conceive with new partner wants to cryopreserve semen to keep all options open wants to conceive with partner (trans male) wants to cryopreserve semen to keep all options open, partner (cis male) has active child wish Physical changes after cessation increased hair growth and transpiration, higher volume of ejaculate unknown none, no hot flushes, no increased hair growth acne Subsequent serum hormone levels - timing 3 months after cessation n.d. n.d. n.d. Estradiol (pmol/L) 82 n.d. n.d. n.d. Testosterone (nmol/L) 17.0 n.d. n.d. n.d. LH (IU/L) 3.1 n.d. n.d. n.d. FSH (IU/L) 9.0 n.d. n.d. n.d. Time after stopping oestrogen (months) 3 3 27** 4 Volume (mL) 1.2 4.5* 2.1* 3.5* Sperm concentration (million/mL) 3.3 48* 77.7* 0.2 Sperm motility (%) 20 69* 51* 19 Time after stopping oestrogen (months) 7 3 n/a n/a Volume (mL) 1.3 5* n/a n/a Sperm concentration (million/mL) 3.8 55* n/a n/a Sperm motility (%) 41* 55* n/a n/a Time after stopping oestrogen (months) 8 3 n/a n/a Volume (mL) 4.8* 6* n/a n/a Sperm concentration (million/mL) 20.2* 53* n/a n/a Sperm motility (%) 48* 75* n/a n/a Time after stopping oestrogen (months) n/a n/a n/a n/a Volume (mL) n/a n/a n/a n/a Sperm concentration (million/mL) n/a n/a n/a n/a Sperm motility (%) n/a n/a n/a n/a