Iris de Nie

Chapter 1 General introduction and thesis outline	7
Chapter 2 Reflecting on the importance of family building and fertility preservation: transgender people’s experiences with starting gender-affirming treatment as adolescent	19
Chapter 3 Impaired semen quality in trans women: prevalence and determinants	35
Chapter 4 A cohort study on factors impairing semen quality in transgender women	51
Chapter 5 Successful restoration of spermatogenesis following gender-affirming hormone therapy in transgender women	67
Chapter 6 Histological study on the influence of puberty suppression and hormonal treatment on developing germ cells in transgender women	81
Chapter 7 Incidence of testicular cancer in trans women using genderaffirming hormonal treatment: a nationwide cohort study	109
Chapter 8 Prostate cancer incidence under androgen deprivation: nationwide cohort study in trans women receiving hormone treatment	121
Chapter 9 General discussion and future perspectives	133
References	144
List of abbreviations	152
Author affiliations	154
Summary in Dutch – Nederlandse samenvatting	158
Portfolio	164
About the author	168
Acknowledgements – Dankwoord	170

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