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40 Chapter 2 15. Stanworth SJ,WalshTS, Prescott RJ, Lee RJ,Watson DM,Wyncoll DLA. Thrombocytopenia and platelet transfusion in UK critical care: A multicenter observational study. Transfusion. 2013;53(5):1050–8. 16. BaharogluMI, Cordonnier C, Salman RAS, de Gans K, KoopmanMM, Brand A, et al. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet [Internet]. 2016;387(10038):2605–13. Available from: http://dx.doi.org/10.1016/S0140-6736 (16)30392-0 17. Curley A, Stanworth SJ, Willoughby K, Fustolo-Gunnink SF, Venkatesh V, Hudson C, et al. Randomized Trial of Platelet-Transfusion Thresholds in Neonates. N Engl J Med [Internet]. 2019;380(3):242–51. Available from: http://www.nejm.org/doi/10.1056/NEJMoa1807320 18. van de Weerdt EK, Peters AL, Goudswaard EJ, Binnekade JM, van Lienden KP, Biemond BJ, et al. The practice of platelet transfusion prior to central venous catheterization in presence of coagulopathy: a national survey among clinicians. Vox Sang. 2017;112(4):343–51. 19. van de Weerdt EK, Biemond BJ, Zeerleder SS, van Lienden KP, Binnekade JM, Vlaar APJ, et al. Prophylactic platelet transfusion prior to central venous catheter placement in patients with thrombocytopenia: Study protocol for a randomised controlled trial. Trials. 2018;19(1):1–10. 20. Durila M, Lukáš P, Astraverkhava M, Beroušek J, Zábrodskỳ M, Vymazal T. Tracheostomy in intensive care unit patients can be performed without bleeding complications in case of normal thromboelastometry results (EXTEM CT) despite increased PT-INR: A prospective pilot study. BMC Anesthesiol [Internet]. 2015;15(1):1–6. Available from: http://dx.doi.org/10.1186/s12871-015-0073-1 21. Yang L, Stanworth S, Hopewell S, Doree C, Murphy M. Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion [Internet]. 2012 Aug;52(8):1673–86; quiz 1673. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22257164

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