Sanne de Bruin

46 Chapter 2 Table S1 World region n = Australia and New Zealand 11 Caribbean 1 Central America 8 Central Asia 1 Eastern Africa 2 Eastern Asia 4 Eastern Europe 53 Northern Africa 6 Northern America 16 Northern Europe 109 South-Eastern Asia 12 South America 38 Southern Africa 2 Southern Asia 26 Southern Europe 197 Western Asia 45 Western Europe 184 Table S2 ICU specific guideline Available Not available p value General ICU population 7(7-7.5) 7(7-7.5) 0.1341 Acute coronary syndrome 9(8-9.7) 9(8-9.6) 0.1009 Septic shock 7.3(7-8) 7.5(7-8) 0.389 Traumatic brain injury 8(7-9) 8(7-9) 0.9795 ECMO 8(7-9) 8(7.5-9) 0.2455 ARDS 7(7-8) 7.5(7-8) 0.0517 Prolonged weaning 7.5(7-8) 7.4(7-8) 0.9892 Age ≥65 years 7(7-8) 7(7-8) 0.6015 Haematological oncology 7(7-8) 7(7-8) 0.2184 Oncology 7(7-8) 7(7-8) 0.8695 Table S3 (not-ICU specific) Guideline Available Not available p value General ICU population 7(7-7.5) 7(7-7.9) 0.0283 Acute coronary syndrome 9(8-9.7) 9(8-9) 0.8161 Septic shock 7.3(7-8) 7.5(7-8) 0.2662 Traumatic brain injury 8(7-9) 8(7-9) 0.783 ECMO 8(7-9) 8(7-9) 0.2794