Sanne de Bruin

84 Chapter 3 Table S1. Difference between respondents with and without a massive transfusion protocol (continued) Massive transfusion protocol (N= 209) No massive transfusion protocol (N= 192) P-value Other 19(9%) 21(11%) Do you use tranexamic acid in critically ill patients with massive bleeding? Yes 201(96%) 173(90%) 0.019 No 7(3%) 19(10%) What guides your use of tranexamic acid in critically ill patients with massive bleeding? I administer tranexamic acid after viscoelastic testing (TEG/ROTEM) 18(9%) 15(8%) 0.040 I empirically administer TXA 180(86%) 152(79%) Other 4(2%) 5(3%) Primary medical specialty Anesthesiology 127(61%) 116(60%) 0.025 Cardiology 1(0%) 6(3%) Internal medicine 41(20%) 37(19%) Neurology 1(0%) 0(0%) Other (please specify) 31(15%) 16(8%) Pulmology 2(1%) 11(6%)

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