70 Chapter 4 Figure 1. Number of couples who, over follow up, are currently on expectant management or receiving IUI-OS The baseline characteristics for couples who eventually received at least one cycle of IUI-OS within one and a half years after HSG or who remained untreated are summarized in Table 1. Treated couples more often had primary subfertility (73% vs. 60%) compared to couples that were not treated. Female age, median duration of subfertility, total motile sperm count, one-sided tubal pathology and referral status were similar between groups. In the 13 weighted mimicked trial datasets, the standardized mean differences between treated and untreated couples were below 0.10 for all characteristics, indicating that the two groups were well balanced in terms of prognostic factors after weighting. The mean weight used in the pooled dataset was 1.00, indicating that weights are stable and do not artificially inflate sample size. Effect estimates of IUI-OS Starting IUI-OS was associated with increased ongoing pregnancy rates compared to expectant management as shown by an estimated hazard ratio of 1.50 (95%CI: 1.19– 1.89), pooling all 13 mimicked, weighted trial datasets running over 6 months.
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