Aernoud Fiolet

129 Colchicine in Patients with Chronic Coronary Disease Figure 3. Key End Points and their Components. The cause-specific hazard ratios were estimated from Cox proportional-hazard regression analysis with death from noncardiovascular causes or death from any cause as a competing risk event. Myocardial infarction refers to spontaneous (nonprocedural) myocardial infarction. The primary end point in the first low-dose colchicine (LoDoCo) trial was a composite of sudden cardiac death, nonfatal out-of- hospital cardiac arrest, acute coronary syndrome (myocardial infarction or unstable angina irrespective of revascularization), or atherosclerotic ischemic stroke. Any myocardial infarctions refers to either spontaneous or procedural myocardial infarctions. The ratio for new-onset diabetes is presented as a cumulative incidence ratio because time-to-event data were not collected. The size of the data points is inversely proportional to the precision (the standard error of the log of the hazard ratios or cumulative incidence ratio) of the estimates, with larger data points representing more precise estimates. The testing hierarchy for statistical significance was broken at the end point of ischemic stroke.