Aernoud Fiolet

146 Chapter 5 Table S1 LoDoCo2 Key Trial Inclusion and Exclusion Criteria Inclusion criteria Age >35 and <82 years Proven coronary artery disease; as evidenced by coronary angiography, CT coronary angiography or a Coronary Artery Calcium Score (Agatston score >400). Individuals with a history of bypass surgery are only eligible if they have undergone coronary artery bypass surgery more than 10 years before, or have angiographic evidence of graft failure or have undergone percutaneous intervention since their bypass surgery Clinically stable for at least six months Exclusion criteria Women who are pregnant, breast feeding or may be considering pregnancy during the study period Renal impairment as evidenced by a serum creatinine >150 µmol/l or estimated glomerular filtration rate (eGFR) <50mL/min/1.73m2 Severe heart failure – systolic or diastolic NewYork Heart Association Functional classification 3 or 4 Moderate or severe valvular heart disease considered likely to require intervention Dependency or frailty or an estimated life expectancy < 5 years Peripheral neuritis, myositis or marked myo-sensitivity to statins Requirement for long term colchicine therapy for any other reason Current enrollment in another trial