Aernoud Fiolet

196 Chapter 7 Supplementary Table S1B: Individual end points and definitions End point and definition Source Myocardial infarction LoDoCo2 Defined by the ACC/AHA/ESC 3rd third universal definition of (acute) myocardial infarction 1 COPS Detection of a rise and/or fall of cardiac troponin with at least one value above the 99th percentile upper reference limit and with at least one of the following: Symptoms of ischaemia; New or presumed new ST-segment-T wave (ST-T) changes or new left bundle branch block (LBBB); Development of pathological Q waves in the ECG; Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Identification of an intracoronary thrombus by angiography or autopsy 2 COLCOT NA 3 LoDoCo Acute ischemic chest pain associated with a rise in serum troponin above the upper limit of normal Personal communication 4 Stroke LoDoCo2 Ischemic and haemorrhagic stroke Personal communication 1 COPS Ischemic and haemorrhagic stroke Personal communication 2 COLCOT Ischemic and haemorrhagic stroke 3,5 LoDoCo Ischemic and haemorrhagic stroke Personal communication 4 Ischemic stroke LoDoCo2 Ischemic stroke; requires ethological, imaging, or other objective evidence of acute, focal cerebral, spinal, or retinal ischemic injury in a defined vascular distribution; or clinical evidence of acute, focal cerebral spinal cord, or retinal ischemic injury based on symptoms persisting >24 hours or until death, and other aetiologies excluded. Ischemic stroke includes haemorrhagic infarction but not intra- cerebral or subarachnoid haemorrhage. Includes atherosclerotic, cardio-embolic and lacunar stroke. 1 COPS Non-cardioembolic ischaemic stroke; computed tomography (CT)- or magnetic resonance imaging (MRI)-proven ischaemic stroke judged by the treating neurologist as not being due to atrial fibrillation or intracranial haemorrhage 2 COLCOT NA 5 LoDoCo Computed tomography—or magnetic resonance imaging—proven ischemic stroke judged by the treating neurologist as not being due to intracranial haemorrhage Personal communication 4 NA: not available