Aernoud Fiolet

198 Chapter 7 Supplementary Table S2: Risk of bias of individual studies as assessed by the Cochrane risk assessment tool. Studies with intention-to- treat Unique ID Study ID Experimental Comparator Outcome Weight Randomization process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported result Overall Lo-MACE LoDoCo 2013 Colchicine 0.5mg once daily No intervention Major adverse cardiovascular events 1 Low risk Lo-MI LoDoCo 2013 Colchicine 0.5mg once daily No intervention Myocardial infarction 1 Some concerns Lo-Revasc LoDoCo 2013 Colchicine 0.5mg once daily No intervention Coronary revascularization 1 High risk Lo-Death LoDoCo 2013 Colchicine 0.5mg once daily No intervention All-cause death 1 Deft-Revasc Deftereos 2013 Colchicine 0.5mg twice daily Placebo Coronary revascularization 1 Deft-Death Deftereos 2013 Colchicine 0.5mg twice daily Placebo All-cause death 1 Col-MACE COLCOT 2019 Colchicine 0.5mg once daily Placebo Major adverse cardiovascular events 1 Col-Revasc COLCOT 2019 Colchicine 0.5mg once daily Placebo Coronary revascularization 1 Col-Death COLCOT 2019 Colchicine 0.5mg once daily Placebo All-cause death 1 COPS-MACE COPS Colchicine 0.5mg once daily Placebo MACE 1 COPS-Revasc COPS Colchicine 0.5mg once daily Placebo Coronary revascularization 1 COPS-Death COPS Colchicine 0.5mg once daily Placebo All-cause death 1 Lo2-MACE LoDoCo2 2020 Colchicine 0.5mg once daily Placebo Major adverse cardiovascular events 1 Lo2-Revasc LoDoCo2 2020 Colchicine 0.5mg once daily Placebo Coronary revascularization 1 Lo2-Death LoDoCo2 2020 Colchicine 0.5mg once daily Placebo All-cause death 1 ? ? ? ? + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + ? ? + + + + + + + + + + + + + ? ? ? ? ? + + + + + + + + + ! ! ! ! ! ! + + + + + + + + + + ? —