Aernoud Fiolet

220 Chapter 8 Table 1. Baseline Characteristics of Patients in the LoDoCo2 Population by Prior ACS status Characteristic No prior ACS n = 864 % (n) Recent prior ACS 6-24 months n = 1479 % (n) Remote prior ACS 2-7 years n = 1582 % (n) Very remote prior ACS >7 years n = 1597 % (n) p-value* Demographics Age – yr, mean ± SD 67.3 ±7.7 63.7 ±9.1 64.3 ±8.7 68.4 ±7.5 <0.001 Female 16.7 (144) 17.6 (260) 15.7 (248) 12.1 (194) 0.003 Clinical Characteristics Hypertension 57.3 (495) 47.1 (696) 49.2 (779) 52.5 (838) <0.001 Current smoker 8.2 (71) 11.6 (172) 14.1 (223) 11.4 (182) <0.001 Diabetes mellitus 19 (164) 13.8 (204) 17.5 (277) 22.7 (362) <0.001 Insulin dependent 7.2 (62) 4.2 (62) 3.3 (52) 7 (111) <0.001 Creatinine clearance <60ml/min/1.73m 2 5.4 (47) 5.7 (85) 5.7 (90) 5.3 (83) 0.93 Prior coronary revascularization 48.1 (416) 90.9 (1344) 91.6 (1449) 88.4 (1412) <0.001 Coronary artery bypass grafting 10.1 (87) 5.4 (80) 6.1 (96) 28 (447) <0.001 Percutaneous coronary intervention 41 (354) 89.9 (1330) 90.3 (1428) 66.7 (1065) <0.001 History of atrial fibrillation 13 (112) 8.5 (126) 9.1 (144) 16.7 (267) <0.001 Medication at enrollment Single antiplatelet therapy 77.1 (666) 40 (592) 77.4 (1225) 76.3 (1218) <0.001 Dual antiplatelet therapy 12.4 (107) 54.5 (806) 14 (221) 9.1 (146) <0.001 Anticoagulant 11.3 (98) 9.1 (134) 10.1 (160) 17.5 (280) <0.001 No antiplatelet agent or anticoagulant 1 (9) 0.1 (1) 0.2 (3) 0.1 (2) <0.001 Statin 93.4 (807) 94.7 (1400) 93.4 (1478) 94.1 (1503) 0.46 Renin angiotensin inhibitor 60.5 (523) 77.1 (1140) 74.6 (1180) 69.9 (1117) <0.001 Beta-blocker 51.9 (448) 66 (976) 62.2 (984) 63.8 (1019) <0.001 ACS = acute coronary syndrome; SD = standard deviation. *p-value of difference between all subgroups by χ 2 or one-way analysis of variance