Aernoud Fiolet

222 Chapter 8 Table 2. Multivariate analysis of the effect of prior ACS status on the composite primary end point* Subgroup Events Unadjusted† Adjusted for multiple variables‡ % (n/N) HR (95% CI) p-value HR (95% CI) p-value Composite of cardiovascular death, myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization Prior ACS binary No prior ACS 9.0 (78/864) - - - - Prior ACS 8.0 (373/4658) 0.98 (0.77-1.25) 0.87 0.93 (0.73-1.19) 0.58 Prior ACS with time-intervals Recent ACS (6-24 months) 7.1 (105/1479) - - - - Remote ACS (2-7 years) 6.8 (107/1582) 0.89 (0.68-1.17) 0.41 0.88 (0.67-1.15) 0.34 Very remote ACS (>7 years) 10.1 (161/1597) 1.31 (1.02-1.68) 0.03 1.19 (0.92-1.53) 0.18 *Two separate analyses were performed. First, including all patients comparing prior ACS versus no prior ACS. Second, including only patients with prior ACS divided in different time-intervals. †Hazard ratios adjusted for treatment were only marginally different compared to unadjusted hazard ratios (Supplemental Table S1). ‡Adjusted for the baseline characteristics from Table 1 that were independent predictors of the primary end point: Age >70 years, current smoker, non- insulin-dependent diabetes, insulin-dependent diabetes, a history of both coronary artery bypass grafting and percutaneous coronary intervention, a combination of oral anticoagulants with dual antiplatelet therapy, no statin use, and colchicine treatment (Supplemental Table S2). ACS = acute coronary syndrome; CI = confidence interval; HR = hazard ratio.