Aernoud Fiolet

241 Short-term effect of low-dose colchicine on biomarkers Median baseline IL-6 was 2.51 ng/L (IQR 1.59–4.32 ng/L) and after one month 2.22 ng/L (median of the differences -0.36 ng/L, 95%CI -0.70 –-0.01 ng/L, p-value 0.01), corresponding to a median change from baseline of -16% (Fig 3A). In 57% of patients hs-CRP decrease showed concordance with IL-6 decrease. Overall, a change in hs-CRP showed a moderate correlation with change in IL-6 (R = 0.41, p <0.001). The median decrease of hs-CRP and IL6 was consistent among various pro-inflammatory phenotypes such as diabetes, smoking, obesity and independent of statin use. There were no significant differences in baseline level of hs-CRP or IL-6 between these groups. (Table 3 and Fig 4). Fig 2. Boxplot representing change of hs-CRP levels after 30 days of colchicine exposure. The figure shows the change in median hs-CRP levels after 30 days of colchicine exposure. Abbreviations: hs-CRP: High sensitivity C-reactive Protein.