Aernoud Fiolet

242 Chapter 9 Fig 3a. Median change in hs-CRP. The figure shows the median change in hs-CRP and IL-6 levels after 30 days of colchicine exposure. Horizontal lines represent 95% confidence intervals. Abbreviations: hs- CRP, High sensitivity C-reactive Protein; IL-6, interleukin-6. Lipids At baseline mean LDL cholesterol level was 2.38 mmol/L. No significant changes were observed in levels of LDL cholesterol, total cholesterol and triglycerides (Table 2). HDL cholesterol decreased from a mean of 1.16 mmol/L to 1.13 mmol/L (median of the differences -0.03 mmol/L, 95% CI -0.05 to -0.01 mmol/L, p-value <0.01), corresponding with a median change from baseline of -3%. Hematologic markers No change was seen in concentration of hemoglobin, hematocrit or erythrocytes (Table 4). The mean corpuscular volume of the erythrocytes went from baseline 91.47 to 91.17 femtoliter (mean of the differences -0.35 femtoliter, 95%CI -0.68 to -0.03, p-value 0.03).