Aernoud Fiolet

243 Short-term effect of low-dose colchicine on biomarkers The number of leukocytes decreased from a median of 6.99 to 6.62 x 10 9 /l (mean of the differences -0.47 x 10 9 /l, 95% CI –0.47 to -0.74, p-value <0.01), corresponding to a median change from baseline of -7%. The number of thrombocytes decreased from a median of 237.50 to 231.00 x 10 9 /l (median of the differences -11.50 x 10 9 /l, 95%CI -16.50 to -6.50, p-value <0.01), corresponding to a median change frombaseline of -4%. Leukocyte changes were significantly correlatedwith changes in hs-CRP (R = 0.23, p < 0.001). Fig 3b. Absolute change in hs-CRP. The figure shows a waterfall plot of change in hs-CRP from baseline to 30 days after colchicine exposure. Vertical bars in the plot represent individual patients. Abbreviations: hs-CRP, high sensitivity C-Reactive Protein.