Aernoud Fiolet

244 Chapter 9 Renal function Creatinine increased from a mean of 87.90 to 89.53 μmol/L (mean of the differences 1.69 μmol/L, 95%CI 0.10 to 3.28 μmol/L, p-value 0.01), corresponding to a mean change from baseline of 1% (Table 3). Derived mean eGFR was 76.81 ml/min/1.73m2 at baseline and decreased to 74.99 ml/min/1.73m² after 30 days (mean of the differences -1.94 ml/min/1.73m², 95%CI -3.28 to -0.42, p-value 0.01), corresponding to a mean change from baseline of -2%. Mild or moderate renal impairment (eGFR 30 to 60 ml/min/1.73m²) was seen in 11% of patients at baseline and 14% of patients at follow-up. Change in eGFR did not correlate significantly with the change in hs-CRP (R 0.07, p = 0.435). Fig 4. Subgroup changes in hs-CRP. The figure shows the median change in hs-CRP after 30 days of colchicine exposure in four subgroups. An asterisk depicts p-values < 0.05 for the paired and non-paired comparisons. In all subgroups hs-CRP decreased significantly. There was no significant interaction of the subgroups and change in hs-CRP. Abbreviations: hs-CRP, high sensitivity C-Reactive Protein; NS, not significant.