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254 Chapter 9 36. Rudi J, Raedsch R, Gerteis C, Schlenker T, Plachky J, Walter-Sack I, et al. Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment. Scand J Gastroenterol. 1994;29(4):346–51. 37. PlattsSH,FalconeJC,HoltonWT,HillMA,MeiningerGA.Alterationofmicrotubulepolymerization modulates arteriolar vasomotor tone. Am J Physiol Circ Physiol. 1999;277(1):100–6. 38. Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, et al. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Am J Physiol Physiol. 2013;305(10):1466–76. 39. McCambridge J,Witton J, Elbourne DR. Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects. J Clin Epidemiol. 2014. March;67(3):267–77. 40. Brinker S, Pandey A, Ayers C, Price A, Raheja P, Arbique D, et al. Therapeutic Drug Monitoring Facilitates Blood Pressure Control in Resistant Hypertension. J Am Coll Cardiol. 2014. March 4;63(8):834–5.