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282 Chapter 11 CONFLICT OF INTEREST The authors declare they have no conflict of interest. FINANCIAL SUPPORT Supported by the Withering Foundation the Netherlands, the Netherlands Heart Foundation, the Netherlands Organization for Health Research and Development, and a consortium of Teva, Disphar, and Tiofarma. M.J.M.S. and L.T. were funded on a Dutch Heart Foundation Dekker grant (grant 2017T067). D.P.V.dK and LT were supported by a grant of the Dutch Heart Foundation, CVON 2017-05 pERSUASIVE.The drugwas supplied free of charge byTioPharma (Oud-Beijerland, the Netherlands). The funders and drug supplier had no role in study design, data collection and analysis, preparation of the manuscript or decision to publish. ACKNOWLEDGEMENTS The help of the research personnel (Ms Hanneke Bakker, Ms Petra Bunschoten, Ms Marjan van Doorn, Ms Coriet Hobe, Ms Hilde Giezen) at the involved sites and the laboratory staff (Ms Claire Frissen, Ms Daniek Kapteijn &Ms Qiu Ying van de Pol) was highly appreciated.