Aernoud Fiolet

286 Chapter 11 SUPPLEMENTARY MATERIAL Supplemental figure 1. Effect of in vitro NLRP3 inflammasome stimulation on IL-1β levels in medium. In vitro stimulation of THP-1 cells showed a higher level of IL-1 β (30.8 pg/mL ± 3.52 pg/mL) compared to unstimulated control cells (7.97 ± 6.75 pg/mL) (difference 22.9 pg/mL, 95% CI 1.717 to 44.01) P value (*<0.05). Abbreviations: IL, interleukin; NLRP3, nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3