Aernoud Fiolet

299 Predictors of early intolerance to low-dose colchicine in patients with coronary disease Figure 2: Univariable and multivariable associations of intolerance due to any percieved side effect. Crude OR Adjusted OR Predictors OR 95% confidence interval P Value OR 95% confidence interval P Value Forrest plot Female sex 1.57 (1.19 to 2.05) 0.001 1.61 (1.21 to 2.11) 0.001 Age above 70 years 1.36 (1.07 to 1.73) 0.011 1.25 (0.97 to 1.61) 0.085 Non caucasian race 1.04 (0.51 to 1.92) 0.897 1.10 (0.53 to 2.03) 0.786 Active smoker 0.83 (0.59 to 1.15) 0.279 0.87 (0.61 to 1.21) 0.425 Obesity 0.69 (0.54 to 0.88) 0.003 0.72 (0.56 to 0.93) 0.012 Hypertension 1.05 (0.83 to 1.32) 0.685 1.01 (0.79 to 1.3) 0.906 Diabetes 0.82 (0.59 to 1.11) 0.220 0.94 (0.65 to 1.33) 0.748 Diabetes on insulin 0.56 (0.28 to 1.02) 0.083 0.59 (0.27 to 1.16) 0.148 eGFR < 60 ml/min/1.73m2 1.36 (0.93 to 1.94) 0.096 1.26 (0.85 to 1.81) 0.236 History of myocardial infarction 0.87 (0.69 to 1.09) 0.219 0.89 (0.7 to 1.14) 0.367 History of LVEF < 50% 1.21 (0.84 to 1.70) 0.290 1.41 (0.96 to 2.01) 0.069 History of atrial fibrillation 1.07 (0.76 to 1.48) 0.696 1.30 (0.74 to 2.28) 0.365 Anticoagulant use 0.96 (0.69 to 1.33) 0.829 0.72 (0.41 to 1.25) 0.257 Beta-blocker use 0.92 (0.73 to 1.17) 0.504 0.92 (0.72 to 1.18) 0.490 Calcium-channel blocker 1.11 (0.84 to 1.45) 0.458 1.12 (0.84 to 1.48) 0.427 Renin angiotensin inhibitor use 0.87 (0.69 to 1.12) 0.279 0.91 (0.71 to 1.18) 0.470 High-dose statin use 0.93 (0.74 to 1.17) 0.527 1.10 (0.85 to 1.41) 0.471 Very high-dose statin use 0.66 (0.47 to 0.92) 0.016 0.64 (0.44 to 0.92) 0.018 Ezetimibe use 0.76 (0.56 to 1.01) 0.060 0.78 (0.58 to 1.03) 0.092 Figure 2: Univariable and multivariable associations of intolerance due to any percieved side effect to low-dose colchicine. All predictors of the unvariable model were entered in the multivariable model. Abbrevations: eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; OR, odds ratio Figure 2: Univariable and multivariable associations of intolerance due to any percieved side effect to low-dose colchicine. All predictors of the unvariable model were entered in the multivariable model. Abbrevations: eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction; OR, odds ratio Univariable and multivariable predictors of intolerance due to any perceived side effect Crude associations of intolerance due to any perceived side effects are depicted in Figure 2 . Significantly increased rates of intolerance were seen for female sex and higher age: intolerance among female participants was 10.9% versus 7.3% in male participants (odds ratio, 1.57; 95% confidence interval 1.19 to 2.05, p = 0.001). In participants aged 70 years or older, intolerance was 9.5% as compared to 7.2% in those younger than 70 years (odds ratio, 1.36; 95% confidence interval 1.07 to 1.73, p = 0.011). Obesity was associated with lower odds for intolerance, with 7.2% of obese participants being intolerant versus 10.1% of participants without obesity. Impaired renal function did not lead to statistically significant differences in intolerance (odds ratio, 1.36; 95% confidence interval 0.93 to 1.94, p = 0.096). No association with intolerance to any perceived side effects and left ventricular ejection fraction < 50% was observed (odds ratio, 1.21; 95% confidence interval 0.84 to 1.70, p = 0.290). In a multivariable model, the univariable association of age and intolerance appeared to be explained by other confounding factors. However, female sex (odds ratio, 1.61; 95% confidence interval 1.21 to 2.11, p < 0.01), obesity (odds