Aernoud Fiolet

346 Chapter 14 Not identified endpoints A total of 24 investigator-reported endpoints were not identified in the process of EHR data retrieval and manual validation (Table 1). Reasons for missing endpoints were absence of EHR entries of the endpoint (6 endpoints), misidentification of the endpoint by EHR data retrieval (2 endpoints) and misclassification of endpoints yielded by EHR data retrieval during manual validation of results (16 endpoints). The distribution of reasons for missed endpoints was similar for the adjudicated endpoints. Figure 3: Cumulative incidence of the primary endpoint (MACE) and secondary endpoint (MACE+). The upper two panels show the cumulative incidence of the primary composite endpoint of cardiovascular death, myocardial infarction, or ischemic stroke, and the secondary composite endpoint of cardiovascular death, myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization stratified per collection method of endpoints. The lower four panels show the cumulative incidence of all-cause mortality and the individual components of the composites. The inset in the two upper panels show the same data on an enlarged y axis. Abbreviations: MACE: major adverse cardiovascular event, EHR: electronic health record.