Aernoud Fiolet

353 Accuracy of using routinely collected electronic healthcare data to identify cardiovascular endpoints Table S2: Accuracy of EHR data retrieval as compared to investigator-reported endpoints and adjudicated endpoints TP FP TN FN Sensitivity (95% CI) Specificity (95% CI) PPV NPV Reference: Investigator-reported Endpoints MACE 47 147 945 4 92.2% (81.1% to 97.8%) 86.5% (84.4% to 88.5%) 24.2% 99.6% MACE+ 94 177 796 20 82.5% (74.2% to 88.9%) 81.8% (79.2% to 84.2%) 34.7% 97.5% Individual Endpoints All-cause Mortality 10 2 933 0 100.0% (69.2% to 100.0%) 99.8% (99.2% to 100.0%) 83.3% 100.0% Cardiovascular Death 6 6 933 0 100.0% (54.1% to 100.0%) 99.4% (98.6% to 99.8%) 50.0% 100.0% Myocardial Infarction 36 138 837 2 94.7% (82.3% to 99.4%) 85.8% (83.5% to 88.0%) 20.7% 99.8% Ischemic Stroke 5 7 933 2 71.4% (29.0% to 96.3%) 99.3% (98.5% to 99.7%) 41.7% 99.8% Venous-thrombotic Embolism 4 4 936 1 80.0% (28.4% to 99.5%) 99.6% (98.9% to 99.9%) 50.0% 99.9% NewAtrial Fibrillation 19 22 902 2 90.5% (69.6% to 98.8%) 97.6% (96.4% to 98.5%) 46.3% 99.8% New Diabetes Mellitus 9 27 908 1 90.0% (55.5% to 99.7%) 97.1% (95.8% to 98.1%) 25.0% 99.9% Ischemia-driven Coronary Revascularization 47 30 875 16 74.6% (62.1% to 84.7%) 96.7% (95.3% to 97.8%) 61.0% 98.2% Reference: Adjudicated Endpoints MACE 41 155 945 4 91.1% (78.8% to 97.5%) 85.9% (83.7% to 87.9%) 20.9% 99.6% MACE+ 87 187 796 18 82.9% (74.3% to 89.5%) 81.0% (78.4% to 83.4%) 31.8% 97.8% The primary endpoint (MACE) was the composite of cardiovascular death, myocardial infarction, or ischemic stroke. The secondary endpoint (MACE+) was the composite of cardiovascular death, myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization. Abbreviations: FN: false negative; FP: false positive; MACE: major adverse cardiovascular event; NP; negative predictive value; PPV, positive predictive value; TN: true negative; TP: true positive.