Aernoud Fiolet

366 Chapter 15 Table 2. Randomised clinical trials of colchicine. Completed clinical trials or registered on ClincialTrials.gov as either not yet recruiting, enrolling, or enrolling by invitation with >100 targeted enrolment and including cardiovascular or all-cause mortality as end points, stratified by long term and short term use (≤90 days ) Accessed August 18 th , 2021 Principle investigator Acronym; trial registration Study name Patients Population Regimen (Expected) Follow-up Primary end point (Estimated) completion date Long term use Nidorf M LoDoCo; ACTRN 12610000293066 Low-Dose Colchicine 532 Chronic coronary disease Colchicine 0.5 mg once daily vs usual care 36 months (median) Composite of acute coronary syndrome, fatal or nonfatal out-of-hospital cardiac arrest, and noncardioembolic ischemic stroke 2013 Deftereos S No acronym; no trial registration Colchicine Treatment for the Prevention of Bare-Metal Stent Restenosis in Diabetic Patient 196 Acute coronary syndrome or chronic coronary disease and diabetes Colchicine 0.5 mg twice daily vs placebo 6 months In-stent restenosis 2013 Nidorf M LoDoCo2; ACTRN12614000093684 Low-Dose Colchicine 2 5522 Chronic coronary disease Colchicine 0.5 mg once daily vs placebo 29 months (median) Cardiovascular death, spontaneous myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularisation 2020 Tong D COPS; ACTRN12615000861550. Colchicine in Patients With Acute Coronary Syndromes 795 Acute coronary syndrome Colchicine 0.5 mg twice daily for the first month, then Colchicine 0.5 mg once daily for 11 months vs placebo 12 months Composite of all-cause mortality, acute coronary syndrome, ischemia- driven unplanned urgent revascularisation, and noncardioembolic ischemic stroke 2020 Tardif JC COLCOT; NCT02551094 Colchicine Cardiovascular Outcomes Trial 4745 Myocardial infarction in previous 30 days Colchicine 0.5 mg once daily vs placebo 23 months (median) Composite of death from cardiovascular causes, resuscitated cardiac arrest, myocardial infarction, stroke, or urgent hospitalisation for angina leading to coronary revascularisation 2020