Aernoud Fiolet

368 Chapter 15 Table 2. Continued. Principle investigator Acronym; trial registration Study name Patients Population Regimen (Expected) Follow-up Primary end point (Estimated) completion date Shvartz V COCS; NCT04224545 Colchicine in Cardiac Surgery 1000 Elective cardiac surgery (coronary artery bypass surgery and/or aortic valve replacement) and sinus rhytm Colchicine 1 mg once daily vs placebo for 5 days 5 days Postoperative atrial fibrillation End 2021 Benz A IMPROVE-PVI Pilot; NCT04160117 Impact of Short- course Colchicine Versus Placebo After Pulmonary Vein Isolation 200 Catheter-guided first or repeat pulmonary vein isolation for atrial fibrillation Colchicine 0.6 mg twice daily vs placebo for 10 days 6 months Average monthly enrollment rate, compliance with study treatment, rate of complete follow-up at 6 months Begin 2022 Beanlands R CADENCE; NCT04181996 Canadian Study of Arterial Inflammation in Patients With Diabetes and Vascular Events: Evaluation of Colchicine 115 Acute coronary syndrome or stroke in previous 30-90 days and diabetes mellitus type II or pre-diabetes Colchicine 0.6 mg once daily vs placebo 6 months Change in fludeoxyglucose uptake (in Tissue-to-Blood- Ratio) End 2023 Pascual Figal D COLICA; NCT04705987 Randomised Double-blind Trial to Study the Benefit of Colchicine in Patients With Acutely Decompensated Heart Failure 278 Congestive heart failure requiring treatment with intravenous diuretics Colchicine 0.5 mg once daily vs placebo for 10 weeks 2 months NT-proBNP levels Mid 2023