Aernoud Fiolet

46 Chapter 1 115. Deftereos S, Giannopoulos G, Raisakis K, et al. Colchicine treatment for the prevention of bare- metal stent restenosis in diabetic patients. J Am Coll Cardiol. 2013;61:1679–85. 116. Cronstein BN, Molad Y, Reibman J, Balakhane E, Levin RI, Weissmann G. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest. 1995;96:994–1002. 117. Menche D, Israel A, Karpatkin S. Platelets and microtubules. Effect of colchicine and D2O on platelet aggregation and release induced by calcium ionophore A23187. J Clin Invest. 1980;66:284–91. 118. Shah B, Allen N, Harchandani B, et al. Effect of Colchicine on Platelet-Platelet and Platelet- Leukocyte Interactions: a Pilot Study in Healthy Subjects. Inflammation. 2016;39:182–9. 119. Munos B. Lessons from60 years of pharmaceutical innovation. Nat RevDrug Discov. 2009;8:959– 68. 120. Martin L, Hutchens M, Hawkins C, Radnov A. How much do clinical trials cost? Nat Rev Drug Discov. 2017;16:381. 121. Shaughnessy AF. Old drugs, new tricks. BMJ. 2011;342:d741. 122. McCann SR. Serendipity in medicine and wine. Bone Marrow Transplant. 2021;56:1487–9. 123. Ban TA. The role of serendipity in drug discovery. Dialogues Clin Neurosci. 2006;8:335. 124. Mukherjee S. Dyeing and Dying. The Emperor of All Maladies: A Biography of Cancer, NewYork City: Simon and Schuster; 2011, p. 87–8. 125. Rich RM, Rosenfeld PJ, Puliafito CA, et al. Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina. 2006;26:495– 511. 126. Fuster V, Sweeny JM. Aspirin: a historical and contemporary therapeutic overview. Circulation. 2011;123:768–78. 127. Pantziarka P, Pirmohamed M, Mirza N. New uses for old drugs. BMJ. 2018;361.

RkJQdWJsaXNoZXIy ODAyMDc0