Aernoud Fiolet

Chapter 1 General introduction and thesis outline 11 PART I: The role of crystal-induced inflammation in atherosclerosis Chapter 2 Viewing Atherosclerosis through a Crystal Lens: How the Evolving Structure of Cholesterol Crystals in Atherosclerotic Plaque Alters its Stability Journal of Clinical Lipidology 2020;14:619-630 51 Chapter 3 Colchicine in Stable Coronary Artery Disease Clinical Therapeutics 2019;41:30-40 73 PART II: Efficacy and safety of colchicine in coronary disease Chapter 4 The effect of low-dose colchicine in patients with stable coronary artery disease: The LoDoCo2 trial rationale, design, and baseline characteristics American Heart Journal 2019;218:46-56 93 Chapter 5 Colchicine in Patients with Chronic Coronary Disease New England Journal of Medicine 2020;383:1838-1847 117 Chapter 6 Reply. Colchicine in Patients with Chronic Coronary Disease New England Journal of Medicine 2021;384:776-779 161 Chapter 7 The efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomised trials European Heart Journal 2021;42:2765-2775 173 Chapter 8 Colchicine in chronic coronary disease in relation to history of acute coronary syndrome Journal of the American College of Cardiology 2021;78:859-866 215 PART III: Insights in mechanism and tolerance Chapter 9 Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein PLOS ONE 2020;15:e0237665 233 TABLE OF CONTENTS