Aernoud Fiolet

83 Colchicine in Stable Coronary Artery Disease Table III. Summary of systematic meta-analysis investigating the effect of colchicine on all-cause mortality and myocardial infarction in patients with various conditions and patients with cardiovascular disease Author, year Total number of patients Number of trials Quality of evidence Population Results Effect estimate Hemkes et al, 2014 44 4,992 39 “Low to moderate” All patients No effect on all-cause mortality RR 0.94 (95%CI 0.82 - 1.09) Limited evidence for a reduction in myocardial infarction RR 0.20 (95%CI 0.07 - 0.57) Verma et al, 2015 45 1,301 5 “Relatively high” Patients with various cardiovascular diseases No effect on all-cause mortality RR 0.50 (95%CI 0.23 - 1.08) Reduction in composite cardiovascular outcomes RR 0.44 (95% CI 0.28 - 0.69) Abbreviations: CI, confidence interval. RR, relative risk.