Aernoud Fiolet

Chapter 1 General introduction and thesis outline 11
Chapter 2 Viewing Atherosclerosis through a Crystal Lens: How the Evolving Structure of Cholesterol Crystals in Atherosclerotic Plaque Alters its Stability 51
Chapter 3 Colchicine in Stable Coronary Artery Disease 73
Chapter 4 The effect of low-dose colchicine in patients with stable coronary artery disease: The LoDoCo2 trial rationale, design, and baseline characteristics 93
Chapter 5 Colchicine in Patients with Chronic Coronary Disease 117
Chapter 6 Reply. Colchicine in Patients with Chronic Coronary Disease 161
Chapter 7 The efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomised trials 173
Chapter 8 Colchicine in chronic coronary disease in relation to history of acute coronary syndrome 215
Chapter 9 Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein 233
Chapter 10 Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease. A LoDoCo2 Proteomic Substudy 257
Chapter 11 Colchicine reduces extracellular vesicle NLRP3 inflammasome protein levels in vitro and in vivo in chronic coronary disease: a LoDoCo2 substudy 267
Chapter 12 Predictors of early intolerance to low-dose colchicine in patients with coronary disease 291
Chapter 13 Text-mining in electronic healthcare records can be used as efficient tool for screening and data collection in cardiovascular trials: a multicenter validation study 313
Chapter 14 Accuracy of using routinely collected electronic healthcare data to identify major cardiovascular endpoints in randomized controlled trials: a multicenter validation study 337
Chapter 15 Clinical implications and future perspectives 359
Chapter 16 Summary 381
Summary in Dutch 391
List of publications 399
Acknowledgements 405
About the author 419

RkJQdWJsaXNoZXIy ODAyMDc0