McCabe score: pto McCabe score: Classification of the severity of underlying medical conditions. Disregard the influence of an active HAI, i.e. estimate the score the patient had before the infection, in this study: at admission in the hospital. Some examples of diseases and their different McCabe score categories are given below. These examples, in particular those of the second (ultimately fatal) category, are not meant to be exhaustive but rather to serve as a guidance tool for the current protocol. Rapidly fatal (survival < one year) End‐stage haematological malignancies (unsuitable for transplant, or relapsed), heart failure (EF < 25%) and end‐stage liver disease (unsuitable for transplant with recalcitrant ascites, encephalopathy or varices) Pulmonary disease with cor pulmonale Ultimately fatal: (1 ≤ survival < 5 years) Chronic leukaemia’s, myelomas, lymphomas, metastatic carcinoma, end‐stage kidney disease (without transplant) Motor neuron disease, multiple sclerosis non‐responsive to treatment Alzheimer’s/dementia Diabetes requiring amputation or post amputation Non‐fatal (survival ≥ five years) Diabetes Carcinoma/haematological malignancy with > 80% five‐year survival Inflammatory disorders Chronic GI, GU conditions Obstetrics Infections (including HIV, HCV, HBV – unless in above categories) All other diseases EF: Ejection fraction, GI: Gastrointestinal, GU: Genitourinary, HCV: Hepatitis C virus, HBV: Hepatitis B virus Reason for ICU admission (with Apache II score) Respiratory: O Asthma/allergy O COPD O Pulmonary edema (non‐ cardiogenic) O Postrespiratory arrest O Aspiration/poisoning/toxic O Pulmonary embolus O Infection O Neoplasm Cardiovascular: O Hypertension O Rhythm disturbance O Congestive heart failure O Hemorrhagic shock/hypovolemic O Coronary artery disease O CABG (coronary artery bypass graft) Cardiovascular (continued): O Sepsis O Postcardiac arrest O Cardiogenic shock O Dissecting thoracic/abdominal aneurysm Trauma (non‐surgical): O Multiple trauma O Head trauma Neurologic (non‐surgical): O Seizure disorder O ICH/SDH/SAH (intracerebral/subdural/subar achnoid hemorrhage) Non‐surgical (not otherwise specified): O Metabolic/renal O Respiratory O Neurologic O Cardiovascular O Gastrointestinal Postoperative O Multiple trauma O Chronic cardiovascular disease O Peripheral vascular surg. O Heart valve surg. O Craniotomy for neoplasm O Renal surg. for neopl. O Renal transplant O Head trauma O Thoracic surg. for neopl. O Craniotomy for ICH/SDH/SAH O Laminectomy and other spinal surgery O Hemorrhagic shock O GI bleeding O GI surgery for neoplasm O Respiratory insufficiency after OR O GI perforation/ obstruction O Postop Sepsis O Postop postarrest Postoperative (not otherwise specified) O Neurologic O Cardiovascular O Respiratory O Gastrointestinal O Metabolic/renal Other O Drug overdose O Diabetic ketoacidosis O GI bleeding 6 131 Mortality review reproducibility study
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