Supplementary Table S4: (Weighted) kappa and percentage agreement for independantly assessed patient and HAI characteristics. Weighed kappa for severity of HAI, presence of competing cause, presence of pathophysiological mechanism, expected mortality at hospital admission and adequacy of antibiotics. Overall BSI Pneumonia CDI SSI (Weighted) kappa (95% CI) % agree ment (Weighted) kappa (95% CI) % agree ment (Weighted) kappa (95% CI) % agree ment (Weighted) kappa (95% CI) % agree ment (Weighted) kappa (95% CI) % agree ment Severity of HAI 0.70 (0.60 – 0.81) 90.4 0.68 (0.41 – 0.94) 94.3 0.67 (0.51 – 0.83) 87.6 0.75 (0.59 – 0.90) 87.3 1.00 (1.00 – 1.00) 100.0 Competing cause 0.67 (0.56 – 0.78) 87.6 0.74 (0.58 – 0.89) 88.5 0.49 (0.24 – 0.73) 87.6 0.63 (0.35 – 0.90) 88.6 0.73 (0.47 – 0.99) 80.0 Pathophysiological mechanism* 0.72 (0.65 – 0.80) 80.7 0.56 (0.39 – 0.74) 77.0 0.79 (0.70 – 0.88) 84.1 0.65 (0.49 – 0.80) 75.7 0.81 (0.48 – 1.00) 95.0 HAI or complication active 0.80 (0.71 – 0.90) 94.5 0.84 (0.63 – 1.00) 97.7 0.77 (0.62 – 0.93) 93.8 0.81 (0.67 – 0.95) 91.5 0.64 (0.01 – 1.00) 95.0 Expected mortality at hospital admission (n=232)* 0.72 (0.64 – 0.80) 84.5 0.74 (0.60 – 0.88) 83.8 0.82 (0.70 – 0.94) 88.2 0.49 (0.32 – 0.66) 76.5 1.00 (1.00 – 1.00) 100.0 Adequacy of AB treatment (n=260) 0.88 (0.82 – 0.95) 95.8 0.91 (0.80 – 1.00) 92.0 0.86 (0.74 – 0.98) 94.9 0.65 (0.20 ‐1.00) 96.6 0.91 (0.74 – 1.00) 95.0 * Significantly different between infection types (p=0.034 and 0.009 respectively) 6 135 Mortality review reproducibility study
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