HH intervention only CVC intervention only Both interventions Baseline Intervention Baseline Intervention Baseline Intervention N % N % p‐value N % N % p‐value N % N % p‐value Type of ICU Cardiothoracic surgery Infectious diseases Intermediate care Medical Medical‐surgical Neurology Neurosurgery Surgery Vascular surgery 0 0 0 0 2898 0 0 0 0 0 0 0 0 100.0 0 0 0 0 0 0 0 0 5273 0 0 0 0 0 0 0 0 100.0 0 0 0 0 1.00 4478 307 16 875 1582 168 98 140 0 58.4 4.0 0.2 11.4 20.6 2.2 1.3 1.8 0 6446 416 12 1179 3290 177 206 335 0 53.4 3.4 0.1 9.8 27.3 1.5 1.7 2.8 0.0 <0.0001 476 0 0 565 1403 33 67 0 125 17.8 0 0 21.2 52.6 1.2 2.5 0 4.7 2305 0 0 440 2031 13 126 0 351 43.8 0.0 0.0 8.4 38.6 0.2 2.4 0.0 6.7 <0.0001 ICU stayb until insertion 0 days 1‐5 6‐20 >20 missing 222 1762 581 333 0 7.7 60.8 20.0 11.5 0.0 256 2996 1160 858 3 4.9 56.8 22.0 16.3 0.1 <0.0001 213 6441 614 394 2 2.8 84.0 8.0 5.1 0.03 324 10206 940 575 16 2.7 84.6 7.8 4.8 0.1 0.58 76 2110 332 151 0 2.8 79.1 12.4 5.7 0 127 4225 591 323 0 2.4 80.2 11.2 6.1 0.0 0.21 Bacteremia at insertion yes no 160 2738 5.5 94.5 300 4973 5.7 94.3 0.95 192 7472 2.5 97.5 263 11798 2.2 97.8 0.33 195 2474 7.3 92.7 189 5077 3.6 96.4 <0.0001 Insertion department ICU OR Elsewhere 2227 398 273 76.8 13.7 9.4 4157 682 434 78.8 12.9 8.2 0.09 2817 4567 280 36.8 59.6 3.7 4558 7035 468 37.8 58.3 3.9 0.20 2089 525 55 78.3 19.7 2.1 3373 1788 105 64.1 34.0 2.0 <0.0001 Insertion site Subclavian Jugular Femoral Other 817 1489 454 138 28.2 51.4 15.7 4.8 1251 2853 1035 134 23.7 54.1 19.6 2.5 <0.0001 2042 4985 522 115 26.6 65.0 6.8 1.5 3094 8012 755 200 25.7 66.4 6.3 1.7 0.11 1063 1251 309 46 39.8 46.9 11.6 1.7 1320 3008 674 264 25.1 57.1 12.8 5.0 <0.0001
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